Fig. 1

Pre- and postnatal effects of cold stress on BAT and non-shivering thermogenesis. In infancy and adulthood, acute cold exposure activates BAT and increases NST to prevent hypothermia. Prolonged cold exposure recruits BAT, leading to increased capacity of NST and improved cold tolerance. BAT-associated NST capacity in adulthood is also increased by parental cold exposure during the period around fertilization. Modified from Yoneshiro et al. [77]